收稿日期: 2023-01-19
录用日期: 2023-07-07
网络出版日期: 2023-10-28
基金资助
国家自然科学基金(81972695);山东省高等学校青创人才引育计划“免疫微环境与炎症性疾病研究创新团队”
Research progress of MDSCs-targeted immunotherapy for pancreatic cancer
Received date: 2023-01-19
Accepted date: 2023-07-07
Online published: 2023-10-28
Supported by
National Natural Science Foundation of China(81972695);Shandong Province Higher Education Youth Talent Introduction Program "Immune Microenvironment and Inflammatory Disease Research Innovation Team"
胰腺癌（pancreatic cancer，PC）是一种高度恶性的消化系统肿瘤，生存率低且预后较差。大多数胰腺癌患者在疾病早期均无明显临床表现，发现就诊时已处于疾病中晚期。在其发展演变过程中形成了独特且复杂的肿瘤微环境（tumor microenvironment，TME）。由于胰腺癌发病的隐匿性，针对于胰腺癌中晚期患者，仅靠一些传统治疗手段比如手术切除，化疗等显得十分局限，目前缺乏有效的治疗方案。当然，这也与胰腺癌的TME的免疫抑制性有关。一些免疫抑制性细胞，如骨髓源性抑制细胞（myeloid-derived suppressor cells，MDSCs）、调节性T细胞（T-regulatory cells，Treg细胞）等在帮助肿瘤免疫逃逸方面发挥着重要的免疫抑制作用。因此，被认为是治疗胰腺癌的一大难点。近年来，随着对TME的深入研究，免疫治疗也逐渐作为一种新的治疗策略，在多种恶性肿瘤的治疗中取得重大进展。研究发现，靶向MDSC疗法是一种新的且有效的胰腺癌治疗方法。该文就MDSC在TME中发挥的作用及其作为潜在靶点免疫治疗胰腺癌的相关进展进行介绍，以期为胰腺癌等肿瘤的治疗提供新方向。
秦雅含 , 张珂 , 张梦雨 , 沈洁 , 彭美玉 . MDSC靶向免疫治疗胰腺癌的研究进展[J]. 上海交通大学学报（医学版）, 2023 , 43(10) : 1317 -1323 . DOI: 10.3969/j.issn.1674-8115.2023.10.014
Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle and late stage of the disease when they seek treatment.A unique and complex tumor microenvironment (TME) is formed during its development and evolution. Due to the occult nature of pancreatic cancer, for patients with advanced pancreatic cancer, some traditional treatment methods such as surgical resection and chemotherapy are very limited, and there is a lack of effective treatment programs. Of course, this is also related to the immunosuppression of the TME of pancreatic cancer. Some immunosuppressive cells, such as myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs), play an important immunosuppressive role in helping tumor immune escape. Therefore, it is considered to be a major difficulty in the treatment of pancreatic cancer. In recent years, with the in-depth study of TME, immunotherapy has gradually become a new therapeutic strategy, and has made great progress in the treatment of various malignant tumors. The study found that targeted MDSCs therapy is a new and effective treatment for pancreatic cancer.In this paper, we introduce the role of MDSCs in TME and their progress as potential targets for immunotherapy of pancreatic cancer, hoping to provide new directions for the treatment of pancreatic cancer and other tumors.
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