收稿日期: 2023-06-01
录用日期: 2023-10-27
网络出版日期: 2024-02-01
基金资助
2023年苏州市姑苏卫生人才计划;2023年度苏州市基础研究计划(SKY2023110);2022年度苏州市科技计划项目(SKYD2022083);2020年度苏州市科技发展计划项目(SYSD2020079)
Review of the role of collagen in tumorigenesis and development
Received date: 2023-06-01
Accepted date: 2023-10-27
Online published: 2024-02-01
Supported by
2023 Gusu Talent Program;2023 Suzhou Basic Research Plan（Medical Application Basic Research, SKY2023110);2022 Suzhou Science and Technology Plan Project(SKYD2022083);2020 Suzhou Science and Technology Development Plan Project(SYSD2020079)
唐雷 , 徐迎春 , 张凤春 . 胶原蛋白在肿瘤发生和发展中的作用综述[J]. 上海交通大学学报（医学版）, 2023 , 43(12) : 1577 -1584 . DOI: 10.3969/j.issn.1674-8115.2023.12.014
Collagen is one of the most abundant proteins in the body and is the main component of the extracellular matrix. Collagen regulates cellular behavior, and its dysregulation can cause a variety of diseases, including cancer. Collagen in tumors is mainly produced by fibroblasts and plays an important role in cancer progression and metastasis. Collagen can act as a prognostic predictor for cancer patients and may be an effective target for the treatment and prevention of tumor progression and metastasis. Anti-tumor drugs targeting collagen and its receptors may be developed in the future. This review focuses on the newly discovered role of collagen in cancer in recent years, specifically the role of collagen in tumor cell dormancy and immune evasion, and the participation of collagen in tumor cell metabolism.
Key words： collagen; extracellular matrix; cancer progression; tumor metastasis; immune escape
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