收稿日期: 2023-10-09
录用日期: 2023-12-07
网络出版日期: 2024-02-28
A case of chronic myelomonocytic leukemia complicated with immune thrombocytopenia
Received date: 2023-10-09
Accepted date: 2023-12-07
Online published: 2024-02-28
慢性粒?单核细胞白血病（chronic myelomonocytic leukemia，CMML）合并免疫性血小板减少症（immune thrombocytopenia，ITP）十分罕见。该文报告1例采用维奈克拉联合瑞帕妥单抗（一种抗CD20单克隆抗体）及海曲泊帕治疗CMML合并ITP患者的临床资料。CMML和ITP的共存机制需要进一步明确。维奈克拉联合抗CD20单抗及血小板生成素受体激动剂可能是治疗该合并症的有效策略之一。
关键词： 慢性粒?单核细胞白血病; 免疫性血小板减少症; 维奈克拉; 海曲泊帕; 瑞帕妥单抗
刘嘉榆 , 黄方 , 郝思国 . 慢性粒-单核细胞白血病合并免疫性血小板减少症1例[J]. 上海交通大学学报（医学版）, 2024 , 44(2) : 287 -290 . DOI: 10.3969/j.issn.1674-8115.2024.02.016
Chronic myelomonocytic leukemia (CMML) complicated with immune thrombocytopenia (ITP) is rare. This article reports the clinical data of a patient with CMML complicated with ITP treated with a combination of venetoclax, ripertamab (an anti-CD20 monoclonal antibody), and hetrombopag. The coexistence mechanism of CMML and ITP needs to be further clarified. Venetoclax combined with anti-CD20 monoclonal antibody and thrombopoietin receptor agonist may be an effective strategy for the treatment of this complication.
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