目的·评估焦虑障碍患者的焦虑水平、述情障碍程度与其生活质量之间的关系。方法·选择2020年10月1日—2023年3月31日期间在上海交通大学医学院附属精神卫生中心门诊收治的焦虑障碍患者为研究对象，经排除后最终纳入患者438例；其中，广泛性焦虑障碍患者271例，惊恐障碍患者101例，社交焦虑障碍患者48例，场所恐惧症患者12例，特定恐惧症患者6例。分别采用汉密尔顿焦虑量表（Hamilton Anxiety Scale，HAMA）、汉密尔顿抑郁量表-17项（Hamilton Depression Scale-17，HAMD-17）、多伦多述情障碍量表-20项（the twenty-item Toronto Alexithymia Scale，TAS-20）、世界卫生组织生活质量测定简表（World Health Organization Quality of Life Scale-Brief Form Questionnaire，WHOQOL-BREF）评估患者的焦虑水平、抑郁水平、述情障碍程度及生活质量，并对不同亚型焦虑障碍患者的量表得分进行评估。采用Spearman相关系数对焦虑障碍患者的焦虑水平、抑郁水平、述情障碍程度与生活质量进行相关分析，并使用逐步回归模型探索影响焦虑障碍患者生活质量的关键变量。结果·不同亚型焦虑障碍患者在HAMA评分、HAMD-17评分、TAS-20评分间的差异无统计学意义，但在WHOQOL-BRIEF评分上差异具有统计学意义（H=10.076，P=0.039）。Spearman相关分析的结果显示，焦虑障碍患者的WHOQOL-BRIEF评分与HAMA评分、HAMD-17评分、TAS-20评分均呈负相关（r=-0.256，P=0.000；r=-0.311，P=0.000；r=-0.342，P=0.000）。逐步回归分析的结果显示，年龄、HAMA评分、HAMD-17评分及TAS-20评分均对患者的生活质量有较大影响（均P<0.05）。结论·不同亚型焦虑障碍患者的生活质量有所不同，焦虑水平、抑郁水平及述情障碍程度均是影响焦虑障碍患者生活质量的关键变量。

Objective ·To evaluate the relationship between anxiety level, alexithymia degree and quality of life in patients with anxiety disorders. Methods ·Anxiety disorder patients admitted to the outpatient department of Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine from October 1, 2020 to March 31, 2023 were selected as the research subjects, and 438 patients were ultimately included after exclusion. Among them, there were 271 patients with generalized anxiety disorder, 101 patients with panic disorder, 48 patients with social anxiety disorder, 12 patients with agoraphobia, and 6 patients with specific phobia. Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale-17 (HAMD-17), the twenty-item Toronto Alexithymia Scale (TAS-20) and World Health Organization Quality of Life Scale-Brief Form Questionnaire (WHOQOL-BREF) were used to assess the patients' anxiety level, depression level, alexithymia degree and quality of life, respectively, and the scale scores of patients with different subtypes of anxiety disorders were evaluated. Spearman correlation coefficient was used to analyze the correlation between anxiety level, depression level, alexithymia degree and quality of life in patients with anxiety disorders. Stepwise regression model was used to analyze the key variables affecting the quality of life in patients with anxiety disorders. Results ·There were no significant differences in HAMA score, HAMD-17 score and TAS-20 score among patients with different subtypes of anxiety disorders, but the differences in WHOQOL-BRIEF score were statistically significant (H=10.076, P=0.039). The results of Spearman correlation analysis showed that the WHOQOL-BRIEF score of anxiety disorder patients was negatively correlated with HAMA score, HAMD-17 score and TAS-20 score (r=-0.256, P=0.000; r=-0.311, P=0.000; r=-0.342, P=0.000). The results of stepwise regression analysis showed that age, HAMA score, HAMD-17 score and TAS-20 score had significant impact on the quality of life of patients (all P<0.05). Conclusion ·The quality of life in patients with different subtypes of anxiety disorders is different. The anxiety level, depression level and alexithymia degree are the key variables affecting their quality of life.