上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2024 , Vol. 44 >Issue 5: 653 - 657

DOI: https://doi.org/10.3969/j.issn.1674-8115.2024.05.015

综述

胶质细胞内SNARE复合体功能及其与抑郁障碍发生的关系

  • 谷涓华 ,
  • 焦扬 ,
  • 鲁琳 ,
  • 王琳琳
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  • 昆明医科大学生物医学工程研究院，昆明 650500
谷涓华（1986—），男，助理实验师，硕士；电子信箱：759210219@qq.com。
王琳琳，电子信箱：82004938@qq.com。

收稿日期: 2023-10-25

  录用日期: 2024-03-05

  网络出版日期: 2024-05-28

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Functions of SNARE complex in glial cells and its relationship with the development of depressive disorder

  • Juanhua GU ,
  • Yang JIAO ,
  • Lin LU ,
  • Linlin WANG
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  • Biomedical Engineering Research Center, Kunming Medical University, Kunming 650500, China
WANG Linlin, E-mail: 82004938@qq.com.

Received date: 2023-10-25

  Accepted date: 2024-03-05

  Online published: 2024-05-28

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摘要

抑郁障碍是现代人类致残和死亡的一个常见原因，部分患者对现有的抗抑郁障碍药物并不敏感，复发率极高。现有的抗抑郁障碍药物存在许多问题，迫切需要找到一种针对多个靶点的新型抗抑郁药。近年来的研究发现，可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体（soluble N-ethylmaleimide-sensitive factor attachment protein receptor，SNARE）复合体与抑郁障碍发生及进展密切相关。该文总结和归纳了胶质细胞内SNARE复合体在抑郁障碍发生过程中的潜在作用机制，并对相关研究进行综述，以期为临床上开发新型的抗抑郁障碍药物提供新的思路。

关键词： 抑郁障碍; 可溶性N-乙基马来酰亚胺敏感因子附着蛋白受体复合体; 胶质细胞

本文引用格式

谷涓华 , 焦扬 , 鲁琳 , 王琳琳 . 胶质细胞内SNARE复合体功能及其与抑郁障碍发生的关系[J]. 上海交通大学学报（医学版）, 2024 , 44(5) : 653 -657 . DOI: 10.3969/j.issn.1674-8115.2024.05.015

Abstract

Depression is a common cause of human disability and death. Some patients are not sensitive to antidepressants, and also the recurrence rate is very high. Unfortunately, there are many problems with existing antidepressants. So, it is urgent to find a new antidepressant aiming at multiple targets. Recently, researchers have found that soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is closely related to the progression of depression. This review discusses the potential mechanisms of the SNARE complex in glial cells, and hopes to contribute to the understanding of depression and provide new ideas for clinical development of novel antidepressant drugs.

Key words： depression; soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex; glia cells

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