上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2025 , Vol. 45 >Issue 2: 228 - 232

DOI: https://doi.org/10.3969/j.issn.1674-8115.2025.02.012

综述

紫外线诱导的DNA损伤促进皮肤恶性肿瘤发生的研究现状

  • 张博源 ,
  • 姚志荣
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  • 1.上海交通大学医学院附属新华医院皮肤病中心，上海 200092
    2.上海交通大学医学院附属新华医院皮肤科，上海 200092
    3.上海交通大学医学院皮肤病研究所，上海 200092
张博源（1999—），男，博士生；电子信箱：zhangboyuan_sjtu@163.com。
姚志荣，教授，主任医师，博士；电子信箱：yaozhirong@xinhuamed.com.cn。

收稿日期: 2024-09-20

  录用日期: 2025-01-13

  网络出版日期: 2025-02-28

基金资助

国家自然科学基金(81874252)

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Current research on UV-induced DNA damage and its role in promoting the development of skin malignancies

  • ZHANG Boyuan ,
  • YAO Zhirong
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  • 1.Dermatology Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    2.Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
    3.Institute of Dermatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
YAO Zhirong, E-mail: yaozhirong@xinhuamed.com.cn.

Received date: 2024-09-20

  Accepted date: 2025-01-13

  Online published: 2025-02-28

Supported by

National Natural Science Foundation of China(81874252)

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摘要

皮肤恶性肿瘤包括非黑色素瘤皮肤癌和黑色素瘤，发病率高，给人类健康和医疗系统带来了沉重负担，其相关研究工作十分重要。紫外线辐射是皮肤恶性肿瘤的首要危险因素，其主要致癌机制为紫外线诱导DNA损伤导致关键癌基因和抑癌基因突变积累，从而促使相关细胞发生恶性转化，最终形成恶性肿瘤。了解紫外线诱导DNA损伤并促进皮肤恶性肿瘤发生的具体过程将为相关研究的突破提供帮助。基于此，该文围绕紫外线诱导DNA损伤的机制、紫外线诱导的DNA损伤的修复机制、紫外线诱导的DNA损伤与三大皮肤恶性肿瘤发生的关系等方面作一综述。

关键词： 皮肤恶性肿瘤; 紫外线; DNA损伤

本文引用格式

张博源 , 姚志荣 . 紫外线诱导的DNA损伤促进皮肤恶性肿瘤发生的研究现状[J]. 上海交通大学学报（医学版）, 2025 , 45(2) : 228 -232 . DOI: 10.3969/j.issn.1674-8115.2025.02.012

Abstract

Skin malignancies include non-melanoma skin cancers and melanoma, with high incidence rates that pose a significant burden on public health and healthcare systems. Research in this area is crucial. Ultraviolet radiation (UV) is recognized as the primary risk factor for skin malignancies, with its main carcinogenic mechanism involving UV-induced DNA damage, which leads to the accumulation of mutations in key oncogenes and tumor suppressor genes. This accumulation promotes malignant transformation of related cells, ultimately resulting in the formation of malignant tumors. Understanding the specific processes through which UV-induced DNA damage contributes to the development of skin malignancies is crucial for advancing related research. Therefore, this paper focuses on the mechanisms of UV-induced DNA damage, the repair mechanisms for UV-induced DNA damage, and the relationship between UV-induced DNA damage and the occurrence of the three major types of skin malignancies.

Key words： skin malignant tumor; ultraviolet rays; DNA damage

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