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NMDA受体与学习记忆关系的研究进展

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  • 上海交通大学 医学院附属瑞金医院麻醉科, 上海 200025
李 强(1985—), 男, 硕士生;电子信箱: tianhailiqiang@126.com。

网络出版日期: 2010-10-27

基金资助

国家自然科学基金(30400421, 30901410)

Research progress on relationship between NMDA receptors and learning and memory

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  • Department of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, |China

Online published: 2010-10-27

Supported by

National Natural Science Foundation of China, 30400421, 30901410

摘要

突触传递长时程增强(LTP)是神经元可塑性的反映,也是学习和记忆的神经生物学基础。目前,关于其形成机制的研究主要集中于N-甲基-D-天冬氨酸(NMDA)受体。三种不同亚基NR1、NR2、NR3组合成NMDAR,并在其功能中发挥不同作用。该文就NMDA受体在学习记忆机制中的作用作一综述。

本文引用格式

李 强 . NMDA受体与学习记忆关系的研究进展[J]. 上海交通大学学报(医学版), 2010 , 30(10) : 1285 . DOI: 10.3969/j.issn.1674-8115.2010.10.024

Abstract

Long-term potentiation (LTP) is thought to be a model for neuronal plasticity and the neuro-biochemical base of learning and memory. The studies of LTP molecular mechanism focus mainly on N-methyl-D-aspartate (NDMA) receptors. Various combinations of subunits including NR1, NR2, NR3 assemble to form NMDAR and generate diversity in its functions. The effects of NMDA receptors on learning and memory are reviewed in this paper.

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