上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2010 , Vol. 30 >Issue 12: 1550

DOI: https://doi.org/10.3969/j.issn.1674-8115.2010.12.024

综述

microRNA-155与恶性肿瘤的关系

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  • 上海交通大学 医学院附属第九人民医院口腔黏膜科 上海市口腔医学重点实验室, 上海 200011
施琳俊（1983—）, 男, 博士生；电子信箱: shi-linjun@hotmail.com。

网络出版日期: 2010-12-31

基金资助

国家自然科学基金（30872887）；上海市科委基金（08DZ2271100）；上海市重点学科建设项目（S30206）

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Relationship between microRNA-155 and malignant tumors

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  • Department of Oral Mucosal Diseases, Shanghai Key Laboratory of Stomatology, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

Online published: 2010-12-31

Supported by

National Natural Science Foundation of China, 30872887；Shanghai Science and Technology Committee Foundation, 08DZ2271100；Shanghai Key Discipline Construction Project, S30206

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摘要

MicroRNA (miRNA)是一种非编码的短链RNA，它在转录后水平调节多个靶基因的表达，因此涉及一系列细胞发育过程的调控。miRNA是近年来生命科学研究的热点，研究表明其与恶性肿瘤的发生密切相关。MicroRNA-155（miRNA-155）来源于活化的淋巴细胞及单核/巨噬细胞内高表达的非编码转录产物，文章就miRNA-155与恶性肿瘤关系的研究进展进行综述。

关键词： microRNA; microRNA-155; 恶性肿瘤; 靶基因

本文引用格式

施琳俊, 周曾同, 蒋伟文 . microRNA-155与恶性肿瘤的关系[J]. 上海交通大学学报（医学版）, 2010 , 30(12) : 1550 . DOI: 10.3969/j.issn.1674-8115.2010.12.024

Abstract

MicroRNAs (miRNAs) are short non-coding RNAs that posttranscriptionally modulate the expression of multiple target genes and are thus implicated in a wide array of cellular and developmental processes. Recently miRNAs and their close associations with malignant tumors remain a major concern. Nowadays microRNA-155(miRNA-155) has been found to be involved in different types of malignant tumors. Here we summarize the research progress of relationship between miRNA-155 and its association with malignant tumors.

Key words： microRNA; microRNA-155; malignant tumor; target gene

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