Research progress of role of statins in treatment of chronic obstractive pulmonary disease
Online published: 2010-12-31
周 健, 凌美蓉, 邓星奇 . 他汀类药物在慢性阻塞性肺疾病治疗中的研究进展[J]. 上海交通大学学报(医学版), 2010 , 30(12) : 1569 . DOI: 10.3969/j.issn.1674-8115.2010.12.028
Chronic obstructive pulmonary disease (COPD) is characterized by progressive and minimally reversible airflow limitation with systemic inflammation, which can be prevented and treated. Statins reduce cholesterol levels by inhibiting 3-hydroxy-3-methlglutaryl coenzyme A(HMG-CoA) reductase, and have an established role in the treatment of cardiovascular diseases. Recent studies have revealed that statins have profound anti-inflammatory effects by reducing induction of matrix metalloproteinase, expression of cytokines and cell adhesion molecules, antioxidant state and C-reactive protein, which decreases lung function deterioration, morbidity and mortality in COPD.
Key words: statins; chronic obstractive pulmonary disease; therapy
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