目的 研究正常眼压性青光眼（NTG）患者眼压的日常波动规律。方法 以35例NTG患者的70眼作为研究对象，按1次/4 h（2:00、6:00、10:00、14:00、18:00、22:00、24:00、4:00、8:00、12:00、16:00、20:00）的时间顺序，用Goldmann压平式眼压计测量眼压。利用SPSS 11.0软件的频数统计、曲线拟合和广义线性模型等程序进行分析。结果 NTG患者的峰值眼压多在12:00（18.6%），而谷值眼压多在24:00（22.9%）；各有50%的患眼在门诊时间（8:00~16:00）内或门诊时间外出现眼压峰值；眼压波动范围在2.3~9.5 mmHg。在各测量时间点，NTG患者的左、右眼的眼压呈高度相关性，且左、右眼的每日曲线轮廓相似。结论 对NTG患者连续监测眼压可避免错过峰值和谷值眼压，有利于治疗。

Objective To investigate the diurnal variation of intraocular pressure in patients with normal tension glaucoma. Methods Intraocular pressure was measured in 35 patients with normal tension glaucoma (70 eyes) by Goldmann applanation tonometer, at 4-hourly intervals for 2 d (2:00, 6:00, 10:00, 14:00, 18:00, 22:00, 24:00, 4:00, 8:00, 12:00, 16:00 and 20:00). The data were analyzed by the frequency, curve estimation and general linear model programs of SPSS11.0 software. Results Most patients with normal tension glaucoma had peak intraocular pressure at 12:00 (18.6%) and trough intraocular pressure at 24:00 (22.9%). The percentage of peak intraocular pressure outside clinic hours (8:00 to 16:00) in patients with normal tension glaucoma was 50%, and the amplitude of variance was 2.3 to 9.5 mmHg. There was a strong positive correlation in intraocular pressure between both eyes at each time point, and the diurnal curves of the right and left eyes had parallel profiles in patients with normal tension glaucoma. Conclusion Serial measurement of intraocular pressure can help to avoid the peak and trough intraocular pressure, and may benefit in the management of glaucoma.