上海交通大学学报（医学版）

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2011 , Vol. 31 >Issue 1: 104

DOI: https://doi.org/10.3969/j.issn.1674-8115.2011.01.024

综述

肝脏卵圆细胞诱导分化为胰岛β细胞的研究进展

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  • 上海交通大学 医学院附属第九人民医院内分泌代谢科, 上海 2000l1
李 影（1984—）, 女, 硕士生；电子信箱: liying1631230@163.com。

网络出版日期: 2011-02-01

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Research progress of trans-differentiation of hepatic oval cells into pancreatic beta cells

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  • Department of Endocrinology and Metabolism, The Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China

Online published: 2011-02-01

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摘要

肝脏卵圆细胞是具有多向分化潜能的干细胞, 在一定的条件下可诱导分化为胰岛β细胞，葡萄糖、细胞外基质、细胞因子和胰岛转录因子等诸多因素均参与分化过程的调控。文章就肝脏卵圆细胞向胰岛β细胞分化的影响因素进行综述。

关键词： 肝脏卵圆细胞; 胰岛β细胞; 糖尿病; 诱导分化; 影响因素

本文引用格式

李 影, 陆颖理 . 肝脏卵圆细胞诱导分化为胰岛β细胞的研究进展[J]. 上海交通大学学报（医学版）, 2011 , 31(1) : 104 . DOI: 10.3969/j.issn.1674-8115.2011.01.024

Abstract

Hepatic oval cells are pluripotent stem cells, which can be induced to trans-differentiate into pancreatic β cells under certain conditions. Many factors such as diabetes mellitus, extracellular matrix, cytokines and pancreatic islet transcription factor may be involved in the trans-differentiation of hepatic oval cells into pancreatic β cells. This article reviews the influential factors in the trans-differentiation of hepatic oval cells into pancreatic β cells.

Key words： hepatic oval cells; pancreatic β cell; diabetes mellitus; trans-differentiation; influential factor

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