目的 比较不同抗菌药物对泛耐药鲍曼不动杆菌（PDR-AB）感染的疗效，为临床抗PDR-AB感染治疗提供有效方案和依据。方法 回顾性分析20例PDR-AB严重感染患者的感染特点、抗菌药物选择及疗效。结果 20例PDR-AB感染患者均接受头孢哌酮－舒巴坦治疗，其中7例为大剂量（9～12 g/d）单独治疗，13例分别联合米诺环素或左氧氟沙星治疗；平均疗程（13.3±5.3）d，临床有效率50.0%，细菌清除率35.0%。10例经上述治疗无效的患者中有5例改为注射硫酸多黏菌素E治疗，平均疗程（16.8±5.0）d，临床有效率80.0%，细菌清除率60.0%。20例患者总临床有效率70.0%，细菌清除率50.0%，病死率30.0%。结论 头孢哌酮－舒巴坦大剂量应用或联合米诺环素对PDR-AB感染有一定疗效，是国内治疗PDR-AB感染的首选；多黏菌素E对PDR-AB感染的疗效也较好，可作为治疗PDR-AB感染的有效选择，但国内尚缺乏上市产品。

Objective To investigate the efficacy of different antibiotics for the treatment of pan-drug-resistant Acinetobacter baumannii (PDR-AB) infection. Methods The clinical characteristics, application of antibiotics and outcomes of 20 patients with severe PDR-AB infection were retrospectively analysed. Results Seven patients were treated with highdose cefoperazone-sulbactam monotherapy (9 to 12 g/d), and the other 13 were managed with cefoperazonesulbactam combined with levofloxacin or minocycline, with the mean course of treatment of (13.3±5.3）d, clinical effective rate of 50.0% and bacteria clearance rate of 35.0%. Five of the 10 patients unresponsive to the initial therapy were administrated with colistin sulfate, with the mean course of treatment of (16.8±5.0）d, clinical effective rate of 80.0% and bacteria clearance rate of 60.0%. For all the 20 patients, the total clinical effective rate was 70.0%, the bacteria clearance rate was 50.0%, and the mortality was 30.0%. Conclusion For the management of PDR-AB infection, highdose cefoperazone-sulbactam with or without minocycline may be effective, and colistin is also viable and safe with a favorable clinical outcome.