目的 观察脱细胞异体真皮基质生物补片修补新生儿和婴幼儿不同类型及部位组织缺损的效果。方法 采用脱细胞异体真皮基质生物补片修补新生儿和婴幼儿组织缺损，其中巨型脐膨出患儿膨出物切除后的腹壁缺损3例、腹壁神经纤维瘤切除后的腹壁缺损 1例、直肠阴道瘘1例、坏死性筋膜炎致臀部皮下组织及皮肤坏死1例。结果 除1例巨型脐膨出患儿家长放弃治疗外，其余患儿恢复良好，无并发症发生。结论 脱细胞异体真皮基质生物补片修补新生儿及婴幼儿不同部位组织缺损的效果良好。

Objective To investigate the application of allogenous acellular dermal matrix biomaterial patches in the repair of tissue defects of different types and positions in neonates and infants. Methods Allogenous acellular dermal matrix biomaterial patches were used in the repair of tissue defects of different types and positions in neonates and infants. There were 3 patients with abdominal wall defect after bulge excision for giant hilum, 1 patient with abdominal wall defect after abdominal fibroma excision, 1 patient with rectovaginal fistula and 1 patient with coxal skin necrosis caused by necrotizing fasciitis. Results One patient with giant hilum resigned from treatment, and the other 5 patients gained favorable recovery, with no complications. Conclusion Allogenous acellular dermal matrix biomaterial patches may yield good outcomes in the repair of tissue defects of different types and positions in neonates and infants.