目的 探讨规范化二级预防措施对急性冠脉综合征患者生活方式的影响。方法 249例急性冠脉综合征患者随机分为强化规范化随访组(n=116)和常规随访组(n=133)。强化规范化随访组每3个月随访一次，随访过程中进行二级预防生活方式的教育，包括戒烟、运动、体质量控制、规范药物服用及压力调节等；常规随访组每6个月随访一次。于随访6个月和1年时点，比较两组患者在戒烟、运动、体质量控制及终点事件（包括心源性死亡、非致死性心肌梗死、靶血管的再次血运重建等）发生方面的差异。结果 218例患者完成6个月随访，103例患者完成1年随访。6个月和1年随访时，强化规范化随访组的戒烟未成功者比例均显著低于常规随访组(P<0.01)，运动达标率均显著高于常规随访组(P<0.05或 P<0.01)。1年随访时，强化规范化随访组超重者比例显著低于常规随访组（P<0.05）；两组均无主要终点事件发生。结论 强化规范化随访能够有效改善急性冠脉综合征患者的生活方式。

Objective To investigate the effects of standardized secondary prevention on lifestyle of patients with acute coronary syndrome. Methods Two hundred and forty-nine patients with acute coronary syndrome were randomly divided into standardized follow-up group (n=116) and routine follow-up group (n=133). Patients in standardized follow-up group were followed up every 3 months, and lifestyle education of secondary prevention was carried out during the follow-up, including smoking quitting, exercise, body weight control, drug use standardization and pressure regulation. Patients in routine follow-up group were followed up every 6 months. At the time points of 6 months of follow-up and 1 year of follow-up, the conditions of smoking quitting, exercise, body weight control and ultimate events (cardiac death, non-lethal myocardial infarction and revascularization of targeted vessels) were compared between groups. Results Two hundred and eighteen patients completed the 6-month follow-up, and 103 patients finished the 1-year follow-up. After follow-up for 6 months or 1 year, the percents of unsuccessful smoking quitting in standardized follow-up group were significantly lower than those in routine follow-up group (P<0.01), and the percents of successful exercise in standardized follow-up group were significantly higher than those in routine follow-up group (P<0.05 or P<0.01). One year after follow-up, the percent of overweight in standardized follow-up group was significantly lower than that in routine follow-up group (P<0.05), and there was no ultimate event in both groups. Conclusion Standardized follow-up can effectively improve the lifestyle of patients with acute coronary syndrome.