目的 探讨手术治疗在非小细胞肺癌（NSCLC）单发脑转移综合治疗中的作用。方法 回顾性分析18例NSCLC单发脑转移患者的临床资料。所有患者在手术切除脑转移瘤后均接受全脑放疗及化疗，其中10例患者接受了肺部肿瘤切除术。结果 患者总中位生存期为20.8个月，1、2和3年生存率分别为83.3%、48.8%和13.9%；接受和未接受肺部肿瘤切除术患者的中位生存期分别为20.5个月和25.5个月，两者比较差异无统计学意义（P=0.536）。结论 手术切除脑转移瘤对NSCLC单发脑转移的治疗具有积极作用；肺部肿瘤是否切除对患者生存期无明显影响。

Objective To investigate the role of surgical resection in comprehensive treatment for patients with non-small cell lung cancer (NSCLC) and solitary brain metastasis. Methods The clinical data of 18 patients with NSCLC and solitary brain metastasis were retrospectively analysed. All patients received both whole brain radiotherapy and chemotherapy after surgical resection of brain metastasis, and 10 of them underwent primary lung tumor resection. Results The median survival time of the patients was 20.8 months, and the 1-year, 2-year and 3-year survival rates were 83.3%, 48.8% and 13.9%, respectively. For the patients with or without primary lung tumor resection, the median survival time was 20.5 months and 25.5 months, respectively (P=0.536). Conclusion Surgical resection of brain metastasis may improve survival of patiens with NSCLC and solitary brain metastasis, while the benefit of primary lung tumor resection on survival of patients is uncertain.