综述

BMP-7介导的间叶-上皮转化与器官纤维化研究进展

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  • 上海交通大学 医学院附属新华医院消化科, 上海 200092
陈丽丽(1985—), 女, 硕士;电子信箱: cllen103@hotmail.com。

网络出版日期: 2011-04-28

基金资助

国家自然科学基金(30971332)

Research progress of BMP-7 induced mesenchymal to epithelial transition in organ fibrosis

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  • Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China

Online published: 2011-04-28

Supported by

National Natural Science Foundation of China, 30971332

摘要

纤维化是各种器官慢性损伤的共同结果。研究发现上皮-间叶转化(EMT)可能是导致多种器官纤维化的潜在机制。目前认为转化生长因子-β1(TGF-β1)能诱导EMT,促进器官纤维化,而骨形态发生蛋白-7(BMP-7)可通过拮抗TGF-β的作用,诱导间叶-上皮转化,改善多种器官纤维化。然而,至今BMP-7的抗纤维化分子机制仍不清楚,对其进行深入研究具有重要意义,可能提供一种纤维化疾病的新治疗手段。

本文引用格式

陈丽丽, 虢灿杰, 陈源文, 等 . BMP-7介导的间叶-上皮转化与器官纤维化研究进展[J]. 上海交通大学学报(医学版), 2011 , 31(4) : 501 . DOI: 10.3969/j.issn.1674-8115.2011.04.028

Abstract

Fibrosis is a common result of chronic injury in many organs. Studies have revealed that epithelial to mesenchymal transition might be the underlying mechanism of fibrotic disorder. Transforming growth factor-β1 has been suggested to induce epithelial to mesenchymal transition and promote organ fibrosis. In contrast, bone morphogenetic protein-7 can block the effect of transforming growth factor-β and induce mesenchymal to epithelial transition which may be helpful to improve organ fibrosis. However, the molecular mechanism of anti-fibrotic effect of bone morphogenetic protein-7 remains unclear. Further studies are of great significance and may provide new therapeutic strategies for organ fibrosis.

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