BMP-7介导的间叶-上皮转化与器官纤维化研究进展
网络出版日期: 2011-04-28
基金资助
国家自然科学基金(30971332)
Research progress of BMP-7 induced mesenchymal to epithelial transition in organ fibrosis
Online published: 2011-04-28
Supported by
National Natural Science Foundation of China, 30971332
陈丽丽, 虢灿杰, 陈源文, 等 . BMP-7介导的间叶-上皮转化与器官纤维化研究进展[J]. 上海交通大学学报(医学版), 2011 , 31(4) : 501 . DOI: 10.3969/j.issn.1674-8115.2011.04.028
Fibrosis is a common result of chronic injury in many organs. Studies have revealed that epithelial to mesenchymal transition might be the underlying mechanism of fibrotic disorder. Transforming growth factor-β1 has been suggested to induce epithelial to mesenchymal transition and promote organ fibrosis. In contrast, bone morphogenetic protein-7 can block the effect of transforming growth factor-β and induce mesenchymal to epithelial transition which may be helpful to improve organ fibrosis. However, the molecular mechanism of anti-fibrotic effect of bone morphogenetic protein-7 remains unclear. Further studies are of great significance and may provide new therapeutic strategies for organ fibrosis.
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