综述

胃癌相关血清标志物的临床意义及研究进展

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  • 上海交通大学 |医学院附属瑞金医院 1.卢湾分院消化内科, 2.临床医学院, 上海 200025
葛沁怡(1986—), 女, 硕士生;电子信箱: tiffanyttg@gmail.com。

网络出版日期: 2011-04-28

Clinical value and research advances of serum tumor markers in gastric cancer

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  • 1.Department of Gastroenterology, Ruijin Hospital Luwan Branch, 2.Department of Clinical Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China

Online published: 2011-04-28

摘要

胃癌是我国最常见的消化道恶性肿瘤之一,早期诊断、早期治疗是提高患者生存期及降低病死率的关键。血清肿瘤标志物检测具有无创、标准化等特点,是近年来众多学者研究的热点。该文针对基因与蛋白水平中近期研究较多的4种胃癌相关的血清标志物(E-cadherin、Runx3、hGC-1和VEGF家族的三个亚型) 作一综述,并分析其对于诊断早期胃癌、监测病情变化及判断预后的应用价值。

本文引用格式

葛沁怡, 胡梅洁 . 胃癌相关血清标志物的临床意义及研究进展[J]. 上海交通大学学报(医学版), 2011 , 31(4) : 505 . DOI: 10.3969/j.issn.1674-8115.2011.04.029

Abstract

Gastric carcinogenesis is one of the most commonly occurring malignant neoplasms in China, and early diagnosis and treatment are crucial to improving the quality of life and reducing mortality rates for patients with gastric cancer. Serumbased detection methods allow for a standardized and non-invasive approach to monitoring progression of gastric cancer. We therefore summarize four serum-based biomarkers (E-cadherin, Runx3, hGC-1 and 3 subtypes of VEGF family) for gastric cancer, categorized into groups of genes and proteins, and evaluate their individual values in detecting gastric cancer, surveillance and evaluating prognosis of patients with gastric cancer.

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