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细胞色素P450 4F2基因多态性的研究进展

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  • 南昌大学 |第二附属医院心胸外科, 南昌 330006
李劼慧(1983—), 男, 主治医师, 硕士;电子信箱: lijiehuimail@qq.com。

网络出版日期: 2011-06-27

Research progress of single nucleotide polymorphisms of cytochrome P450 4F2

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  • The Second Affiliated Hospital to Nanchang University, Nanchang 330006, China

Online published: 2011-06-27

摘要

细胞色素P450(CYP)4F2是CYP的亚型,参与体内一系列生化反应。新近的研究发现了它在心脑血管及血液学领域等方面新的生理机制,由此可以从多个角度全新解释相关领域的疾病及病理生理过程,如原发性高血压、心肌梗死、脑卒中及脂类物质花生四烯酸和药物华法林等在体内的代谢等。

本文引用格式

李劼慧, 徐建军 . 细胞色素P450 4F2基因多态性的研究进展[J]. 上海交通大学学报(医学版), 2011 , 31(6) : 858 . DOI: 10.3969/j.issn.1674-8115.2011.06.040

Abstract

Cytochrome P450 (CYP) 4F2, a member of the CYP4F enzyme subfamily, takes part in a series of biochemical reaction in vivo. Recent researches have revealed the new mechanism the enzyme plays in the cardiovascular and hematological fields, such as essential hypertension, myocardial infarction, stroke and metabolism of arachidonic acid and warfarin.

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