上海交通大学学报（医学版）

上海交通大学学报（医学版） >

2011 , Vol. 31 >Issue 7: 1035

DOI: https://doi.org/10.3969/j.issn.1674-8115.2011.07.037

综述

类风湿性关节炎免疫学研究进展

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  • 1.上海交通大学医学院 上海市免疫学研究所, 上海 200025； 2.上海市徐汇区中心医院, 上海 200031
缪 怡（1976—）, 女, 主管技师, 硕士生；电子信箱: miaoyi040123@yahoo.cn。

网络出版日期: 2011-07-27

基金资助

上海市徐汇区中心医院院基金(2011XHCH07)和上海市科委重点项目（07JC14033和10JC1408500）

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Research progress in immunology of rheumatoid arthritis

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  • 1.Shanghai Institute of Immunology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China；2.Xuhui District Center Hospital of Shanghai, Shanghai 200031, China

Online published: 2011-07-27

Supported by

Foundation of Xuhui District Center Hospital of Shanghai, 2011XHCH07；Key Project of Shanghai Science and Technology Committee, 07JC14033, 10JC1408500

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摘要

类风湿性关节炎（RA）是一类常见的、以四肢关节滑膜炎为特征的慢性自身免疫性疾病。RA是以T淋巴细胞，特别是辅助性T淋巴细胞亚群Th1细胞介导为核心的免疫系统功能紊乱性疾病；B淋巴细胞通过递呈抗原、产生自身抗体和分泌细胞因子也与RA发病密切相关。此外，γδ T淋巴细胞、Th17细胞及细胞因子白介素4（IL-4）和IL-10等也在不同程度上影响着疾病的进程。文章就细胞、抗体和细胞因子与RA发病和诊疗的相关性作一综述。

关键词： 类风湿性关节炎; 自身免疫性疾病; T淋巴细胞; B淋巴细胞; 自身抗体

本文引用格式

缪 怡, 胡朝英, 钱 柳, 等 . 类风湿性关节炎免疫学研究进展[J]. 上海交通大学学报（医学版）, 2011 , 31(7) : 1035 . DOI: 10.3969/j.issn.1674-8115.2011.07.037

Abstract

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation of synovial joints. RA is presented as the malfunction of immune system especially mediated by Th1 cells. B lymphocytes are also closely associated with RA in the process of antigen presentation, antibody generation and cytokine secretion. Besides, γδ T lymphocytes, Th17 cells, interleukin (IL)-4 and IL-10 also function in different stages of RA. This paper discusses the correlation of cells, antibodies and cytokines with the development, diagnosis and treatment of RA.

Key words： rheumatoid arthritis; autoimmune disease; T lymphocyte; B lymphocyte; autoantibody

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