目的 探讨离心泵后负荷压力对血液破坏的影响。方法 采用计算流体仿真（CFD），实现Sarns2000离心血泵的数值分析。对比分析该泵有后负荷工况和空载状态时泵内液体流速、压力、剪切力的差异。结果 在1 400 r/min转速下，有后负荷时流速降低，泵的流量降低。泵内压力增大，溶血破坏增加；但剪切力大于150 Pa的区域小于0.000 032%，对溶血的控制较好。结论 后负荷压力会导致Sarns2000离心泵内溶血破坏的概率增加，但不会出现因剪切力导致大量溶血的问题。

Objective To investigate the effect of afterload pressure on hemolytic blood damage in centrifugal pump. Methods The differences between velocity, pressure and surface shear force of the internal flow of Sarns2000 centrifugal pump with afterload pressure and those without afterload pressure were obtained by computational fluid dynamics(CFD). Results The velocity and flow of pump deceased when the rotational speed was 1 400 r/min with afterload pressure. The hemolytic blood damage increased with the pressure increase in the pump. However, the area whose surface shear force was greater than 150 Pa was less than 0.000032%, which had a good performance of hemolysis. Conclusion The afterload pressure would enhance the possibility of hemolysis in Sarns2000 centrifugal pump, while the surface shear force has a good performance of hemolysis.