目的 探讨抗性淀粉干预糖尿病大鼠对其子代糖代谢的影响。方法 20只6周龄雌性2型糖尿病Goto-Kakizaki（GK）大鼠随机分为抗性淀粉组（GK-RS组，n=10）和等能量密度饲料对照组（GK-EC组，n=10），以喂食等能量密度饲料的同龄Wistar雌鼠作为空白对照组（Wistar-EC组，n=10），分组喂养直至分娩。在各组幼鼠中分别随机选取10只雄性幼鼠，常规饲料喂养至8周龄，每周3次记录体质量和摄食量，免疫组织化学法检测胰腺相对β细胞密度，ELISA法测定空腹血清胰岛素水平，口服葡萄糖耐量试验检测空腹血糖和餐后2 h血糖，以稳态模型的胰岛素抵抗指数（HOMA-IR）评估胰岛素敏感性。结果 与GK-EC 组比较，GK-RS组空腹血糖浓度显著降低（P<0.05），胰腺胰岛素含量明显升高（P<0.05），胰腺相对β细胞密度呈现增高趋势（P=0.07）。GK-EC与GK-RS组幼鼠的摄食量、体质量、HOMA-IR、餐后2 h血糖和血清空腹胰岛素水平比较，差异均无统计学意义（P>0.05）。结论 抗性淀粉干预糖尿病大鼠有益于改善其子代发生的糖代谢紊乱。

Objective To investigate the effects of dietary resistant starch on glucose metabolism in offsprings of diabetic rats. Methods Twenty female Goto-Kakizaki (GK) rats with type 2 diabetes aged 6 weeks were randomized into resistant starch diet group (GK-RS group, n=10) and energy control diet group (GK-EC group, n=10), and another 10 age-matched female Wistar rats fed with energy control diet were served as blank control group (Wistar-EC group). Ten male offsprings were randomly selected in each group, and were raised till 8 weeks old on regular chow diet. Body weight and volume of food intake were recorded three time a week, pancreatic relative β cell density was measured by immunohistochemistry, fasting serum insulin concentration was detected by ELISA, concentrations of fasting blood glucose and 2 h postprandial blood glucose were determined by oral glucose tolerance test, and insulin sensitivity was evaluated by homeostasis model assessment of insulin resistance (HOMA-IR). Results Compared with GK-EC group, the concentration of fasting blood glucose significantly decreased (P<0.05), pancreatic insulin content significantly increased (P<0.05), and pancreatic relative β cell density tended to increase in GK-RS group (P=0.07). There was no significant difference in body weight, volume of food intake, HOMA-IR and concentrations of 2 h postprandial blood glucose and fasting serum insulin between GK-EC group and GK-RS group (P>0.05). Conclusion Dietary resistant starch has potential in improving glucose metabolism disorder in offsprings born to diabetic dams.