目的 了解我国四川省、新疆维吾尔自治区、广西壮族自治区女性性工作者（FSWs）对暴露前预防用药(Pr-EP)预防人类免疫缺陷病毒(HIV)感染的接受意愿及其影响因素。方法 采用问卷调查的形式，调查对象为四川省、新疆维吾尔自治区、广西壮族自治区的FSWs。调查完成问卷1 478份，有效问卷1 469份（占99.39%）。调查内容主要为FSWs对Pr-EP的知晓情况和接受意愿。结果 经调查人员介绍了Pr-EP相关知识后，在Pr-EP安全有效的前提下，共有801人（54.5%）表示“肯定愿意使用”，有196人（13.3%）表示“可能会使用”，Pr-EP使用意愿为67.9%（997/1469），三个地区间的差异无统计学意义(P>0.05)。经过单因素χ²检验和Logistic回归分析，结果显示：Pr-EP的接受意愿的影响因素包括危险自评(OR=1.776，P=0.005)、性服务安全套使用(OR=1.346，P=0.000)、最近三次发生性交易使用安全套的频率(OR=1.519，P=0.003)、是否使用过药物预防性病(OR=1.185，P=0.025)、是否拒绝与不使用安全套的人发生性行为(OR=1.479，P=0.009)、是否会建议朋友接受Pr-EP(OR=5.618，P=0.000)。三个地区FSWs对Pr-EP比较关注的是其安全性/不良反应、效果/有效性、费用。结论 坚持使用安全套的FSWs更倾向于接受Pr-EP；应该加大Pr-EP相关知识的宣传力度，提高FSWs对Pr-EP知晓率，进一步提高FSWs对于Pr-EP的接受意愿；同伴教育可能是推广Pr-EP的有效方式。

Objective To investigate the acceptability and influencing factors of pre-exposure prophylaxis (Pr-EP) for human immunodeficiency virus (HIV) among female sex workers (FSWs) in Sichuan, Xinjiang and Guangxi of China. Methods FSWs selected from Sichuan, Xinjiang and Guangxi were surveyed with questionnaires. A total of 1 478 questionnaires were completed, among which 1 469 (99.39%) were effective. The survey mainly concerned with the awareness and acceptability of FSWs on Pr-EP. Results After introduction to Pr-EP by the investigators, under the precondition that Pr-EP was effective and safe, 997(67.9%) FSWs accepted Pr-EP, and there was no significant difference in the acceptability among FSWs in three regions (P>0.05). Univariate χ² analysis and Logistic regression analysis revealed that self-evaluation of risks (OR=1.776, P=0.005), regular condom use in sex service (OR=1.346, P=0.000), frequency of condom use during the latest three times of sex service (OR=1.519, P=0.003), drug use to prevent sexually-transmitted disease (OR=1.185, P=0.025), refusal of having sex with those without condom use (OR=1.479, P=0.009) and advising peers to use Pr-EP (OR=5.618, P=0.000) were influencing factors of acceptability of Pr-EP. FSWs mainly concerned of the security, effectiveness and cost of Pr-EP. Conclusion FSWs with regular condom use are more likely to accept Pr-EP. Pr-EP related knowledge should be well exposed among FSWs to increase the awareness and acceptability. Peer education may be a better way to improve the acceptability of Pr-EP.