18F-FDG PET/CT全身显像辅助诊断小肠肿瘤的价值
网络出版日期: 2012-06-01
基金资助
上海市重点学科建设项目(S30203);上海高校选拔培养优秀青年教师科研专项基金(jdy09096)
Role of 18F-FDG PET/CT whole body scan in diagnosis of small bowel tumors
Online published: 2012-06-01
Supported by
Shanghai Leading Academic Discipline Project, S30203;Shanghai Research Foundation for Cultivation of Outstanding Young Teachers in Colleges, jdy09096
目的 探讨18F-FDG正电子发射型断层扫描/计算机断层扫描(PET/CT)全身显像辅助诊断小肠肿瘤的临床应用价值。方法 回顾性分析接受过18F-FDG PET/CT全身显像检查、且临床高度怀疑为小肠肿瘤的24例患者的病史资料,将PET/CT检查结果与双气囊小肠镜、活检及手术病理结果进行对照分析。结果 2例经病理证实为肠外恶性肿瘤患者的资料被排除。22例小肠肿瘤患者中,18F-FDG PET/CT全身显像检出小肠恶性肿瘤16例(小肠恶性肿瘤病灶17处,淋巴结受累27处);小肠良性肿瘤及良性病变4例;1例肠结核患者PET/CT检查结果为假阳性;1例小肠印戒细胞癌患者PET/CT检查结果为假阴性。18F-FDG PET/CT诊断小肠恶性肿瘤的灵敏度为94.12%,特异度为80.00%;阳性预测值为94.12%,阴性预测值为80.00%,诊断准确率为90.91%。结论 18F-FDG PET/CT全身显像检查对小肠恶性肿瘤检测、良恶性鉴别、分期及指导临床治疗有较高的应用价值,是一种对小肠肿瘤患者无创、无痛、有效的临床辅助诊断显像技术。
关键词: 小肠肿瘤; 正电子发射型断层扫描; 计算机断层扫描; X线计算机; 诊断
胡佳佳, 王正廷, 钟 捷, 等 . 18F-FDG PET/CT全身显像辅助诊断小肠肿瘤的价值[J]. 上海交通大学学报(医学版), 2012 , 32(5) : 610 . DOI: 10.3969/j.issn.1674-8115.2012.05.017
Objective To investigate the value of 18F-FDG PET/CT whole body scan in the diagnosis of small bowel tumors. Methods The clinical data of 24 patients who had undergone 18F-FDG PET/CT whole body scan and were highly suspected with small bowel tumors were retrospectively analysed, and comparison analysis was conducted between results of PET/CT examinations and findings of double-balloon small bowel endoscopy, biopsy and surgical pathology. Results The data of 2 patients with extra-intestinal malignant tumors confirmed by pathology were excluded. Among the 22 patients with small bowel tumors, 16 patients were diagnosed as small bowel malignant tumors by 18F-FDG PET/CT whole body scan (17 small bowel malignant tumor lesions and 27 involved lymph nodes), 4 patients were diagnosed as small bowel benign tumors and benign lesions, 1 patient with intestinal tuberculosis had false positive PET/CT findings, and 1 patient with small intestinal signet ring cell carcinoma had false negative PET/CT findings. The sensitivity and specificity of 18F-FDG PET/CT in diagnosis of small bowel malignant tumors were 94.12% and 80.00% respectively, and the positive predictive value, negative predictive value and accuracy in diagnosis were 94.12%, 80.00% and 90.91% respectively. Conclusion 18F-FDG PET/CT whole body scan is a feasible, safe, noninvasive and promising diagnostic tool for detecting small bowel malignancies, differentiating benign and malignant tumors, staging and guiding clinical treatment.
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