PI3K/Akt/mTOR信号通路及mTOR抑制剂在泌尿系统肿瘤中的研究进展
网络出版日期: 2012-06-01
基金资助
上海市自然科学基金(10411960000)
Research progress of PI3K/Akt/mTOR signaling pathway and mTOR inhibitors in urologic malignancies
Online published: 2012-06-01
Supported by
Shanghai Natural Science Foundation,10411960000
宿恒川, 孙福康 . PI3K/Akt/mTOR信号通路及mTOR抑制剂在泌尿系统肿瘤中的研究进展[J]. 上海交通大学学报(医学版), 2012 , 32(5) : 674 . DOI: 10.3969/j.issn.1674-8115.2012.05.032
PI3K/Akt/mTOR signaling pathway plays a vital role in the angiogenesis, protein synthesis, cell growth and metabolism, and dysregulation of this pathway has been found in many substantive malignant tumors. In recent years, the inhibitors of PI3K/Akt/mTOR signaling pathway have been developed in succession, which have exhibited definite clinical effects on advanced renal cell carcinoma. As a result, further research on this pathway and its inhibitors, particularly their applications in urologic malignancies, has become one of the hot research areas. This paper focuses on the mechanism of PI3K/Akt/mTOR signaling pathway and its roles in the development of tumors, and the research progress of mTOR inhibitors in urologic malignancies is also reviewed.
Key words: PI3K; Akt; mTOR; signaling pathway; mTOR inhibitors; urinary system; tumors
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