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后抗生素时代我们如何征服细菌?

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  • 上海交通大学 基础医学院病原生物学教研室, 上海 200025
郭晓奎(1964—), 男, 教授, 博士, 博士生导师;电子信箱: microbiology@sjtu.edu.cn。

网络出版日期: 2012-11-30

基金资助

国家高技术研究发展计划(“八六三”计划)(2011AA02A119)

How to conquer bacteria in post-antibiotic era?

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  • Department of Medical Microbiology and Parasitology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China

Online published: 2012-11-30

Supported by

National High Technology Research and Development Program of China, 2011AA02A119

摘要

耐药性“超级细菌”的出现,将使我们重新步入无抗生素可用的时代,即“后抗生素时代”。面对日益严重的细菌耐药性,寻找新的抗菌药物及治疗方案已成为目前急需解决的难题。文章阐述新型抗生素、抗菌肽、噬菌体和中药制剂的研究开发及应用前景,为后抗生素时代针对耐药细菌,特别是超级细菌的抗感染药物的研究提供思路。

关键词: 耐药; 细菌; 控制

本文引用格式

郭晓奎 . 后抗生素时代我们如何征服细菌?[J]. 上海交通大学学报(医学版), 2012 , 32(11) : 1401 . DOI: 10.3969/j.issn.1674-8115.2012.11.001

Abstract

The occurrence of antibiotic resistant bacteria, especially pan-drug resistant bacteria may make no antibiotics available for the treatment of infectious diseases, which will lead to the emerge of post-antibiotic era. It is imperative to find new antibacterial drugs or strategies to solve the increasingly serious problem of drug resistance. The invention status and application prospect of newtype antibiotics, antimicrobial peptide, bacteriophage and traditional Chinese medicine preparation are introduced in this paper, which may provide reference for the exploration of antibacterial drugs to conquer bacteria in post-antibiotic era.

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