网络出版日期: 2012-11-30
基金资助
国家自然科学基金(81171587)
Research progress of bacterial pan-genome
Online published: 2012-11-30
Supported by
National Natural Science Foundation of China, 81171587
庄绪冉, 朱泳璋 . 细菌泛基因组学的研究[J]. 上海交通大学学报(医学版), 2012 , 32(11) : 1440 . DOI: 10.3969/j.issn.1674-8115.2012.11.010
Bacterium, one of the most ancient organisms, has great diversity and obvious differentiation in phenotype among different strains and even in different lines of one strain. The hereditary basis of differentiation is due to the genomic genetic information difference among different strains. In order to illustrate the individual genetic diversity and explore the hereditary basis of individual phylogenesis and phenotype difference, the concept of pan-genome is put forward. The causes of hereditary diversity of bacteria, the research strategy of pan-genome and its application in bacterial research are reviewed in this paper.
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