网络出版日期: 2012-12-31
基金资助
上海市卫生局科研基金(2011213)
Research progress of microRNA in diagnosis, treatment and prognosis evaluation for pancreatic ductal adenocarcinoma
Online published: 2012-12-31
Supported by
Shanghai Health Bureau Foundation, 2011213
张军峰, 花 荣 . 微小RNA在胰腺导管腺癌诊断、治疗和预后评估中的研究进展[J]. 上海交通大学学报(医学版), 2012 , 32(12) : 1646 . DOI: 10.3969/j.issn.1674-8115.2012.12.026
MicroRNA (miRNA) are a class of short noncoding RNAs, with 17-25 nucleotides in length, which play a role in the regulation of gene expression at posttranscriptional level. Recent studies have revealed that miRNA may be associated with pathogenesis, progression, invasion and metastasis of tumors. Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer which is characterized by the absence of biomarkers for early diagnosis and effective strategies for therapeutic intervention. The current status of miRNA in diagnosis, treatment and prognosis evaluation for PDAC is introduced in this paper.
Key words: pancreatic ductal adenocarcinoma; microRNA; tumor biomarker; diagnosis
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