目的 探讨影响负压封闭引流技术（VSD）治疗下肢大面积毁损伤临床效果的因素及有效护理对策。方法 108例下肢大面积毁损伤行急诊手术的患者，术后创面辅以VSD治疗，根据创面大小选用不同数量的VSD薄膜，多根引流管可用三通接头串联引流；分析影响其治疗效果的因素。结果 108例患者中，22例（20.37%）发生管道阻塞，10例（9.26%）创面薄膜漏气，2例（1.85%）引流管接口脱落。对症采取有效的护理措施，以保持引流通畅。结论 大面积毁损伤的创面使用VSD时，实施有效的护理对策能提高VSD的临床治疗效果。

Objective To investigate the influencing factors of clinical effect of vacuum sealing drainage (VSD) treatment of large destructive injury of lower limbs, and explore the effective nursing strategy. Methods One hundred and eight patients subject to emergency operation for large destructive injury of lower limbs were treated with VSD on wound after operation, and different numbers of VSD film were used based on the area of wound. The influencing factors of curative effect were analysed. Results Catheter obstruction happened in 22 patients (20.37%), film leakage occurred in 10 patients (9.26%), and drainage tube slipped off in 2 patients (1.85%). Effective nursing measures were taken based on the symptoms to ensure the unobstructed drainage. Conclusion In VSD treatment of large destructive injury of lower limbs, adoption of effective nursing measures can improve the clinical effects of VSD.