肿瘤通常伴有遗传学和表观遗传学的改变，组蛋白修饰是一种重要的表观遗传学调控方式，常参与肿瘤的发生和发展。研究表明部分包含JmjC结构域的蛋白具有组蛋白去甲基化酶的活性，能够移除组蛋白上的甲基。JmjC家族在肿瘤的发生中发挥重要作用，其机制研究已成为肿瘤表观遗传学研究的热点。文章主要介绍JmjC家族成员的基本信息，并对其在肿瘤发生中的作用进行探讨。

Tumors are often accompanied by genetic and epigenetic changes. Histone modifications, as the important epigenetic regulation, are frequently involved in the initiation and progression of tumors. Recent studies have revealed that some JmjC domain-containing proteins with histone demethylase activity can remove the histone methyl. JmjC family play an important role in the oncogenesis, the mechanism of which has been the hotspot of tumor epigenetic research. This review introduces the general information of JmjC family members, and discusses their role on tumorigenesis.