综述

影响奥氮平诱导的代谢紊乱动物模型可重复性的因素

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  • 1.上海交通大学 医学院附属精神卫生中心, 上海 200030; 2.耶鲁大学医学院内科, 纽黑文 06520
张成芳(1987—), 女, 硕士生; 电子信箱: callup1987@126.com。

网络出版日期: 2013-05-28

基金资助

上海市浦江人才计划(10PJ1408800);国家自然科学基金(81171266);上海市科技创新计划(11140900400);教育部第43批留学回国人员科研启动基金;上海市公共卫生优秀学科带头人培养计划(GWDTR201230);国家自然科学基金(81271481)

Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model

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  • 1.Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China; 2.Department of Internal Medicine, Yale University School of Medicine, New Haven 06520, USA

Online published: 2013-05-28

Supported by

Shanghai Pujiang Talent Program, 10PJ1408800; National Natural Science Foundation, 81171266; Shanghai Science and Technology Innovation Program, 11140900400; Foundation of the Ministry of Education of China for Returned Talents from Overseas; Shanghai Public Health Excellent Discipline Leader Program, GWDTR201230; National Natural Science Foundation of China, 81271481

摘要

新型抗精神病药物奥氮平引起的代谢紊乱倍受瞩目,但机制未明,建立合适的动物模型是研究其不良反应机制的重要方法,而动物模型的稳定性和可重复性十分关键。文章对近年来奥氮平诱导的代谢紊乱的动物模型研究进行归纳,探讨了影响模型重复性的主要因素,旨在为相关研究提供参考。

本文引用格式

张成芳, Dake Qi, 崔东红 . 影响奥氮平诱导的代谢紊乱动物模型可重复性的因素[J]. 上海交通大学学报(医学版), 2013 , 33(5) : 690 . DOI: 10.3969/j.issn.1674-8115.2013.05.037

Abstract

Olanzapine-induced metabolic disorders have been increasingly concerned. However, the mechanism is still unknown. The establishment of an appropriate animal model to explore the mechanism is a most important way, and the stability and reproducibility of an animal model are of vital importance. In this paper, the studies on establishment of Olanzapine-induced metabolic disorder animal models are reviewed, and the influencing factors of the reproducibility of animal models are discussed, hoping to provide reference for the related research.

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