Abstract:

Objective To investigate the risk factors of prognosis of neonatal respiratory failure in late preterm and full-term infants. Methods Sixty-eight neonates with respiratory failure hospitalized in neonatal intensive care unit (NICU) were divided into late preterm infants group (n=34) and full-term infants group (n=34), the general clinical characteristics, perinatal parameters, treatment process of respiratory failure, main disease diagnosis and prognosis evaluation were compared between these two groups. Besides, the clinical parameters and respiratory parameters were compared between favorable prognosis group and unfavorable prognosis group. Results The average birth weight in late preterm infants group was significantly lower than that in full-term infants group (P<0.01), and the proportion of infants with low body weight in late preterm infants group was significantly higher than that in full-term infants group (P<0.05). However, there was no significant difference in the gender constituent ratio, age at NICU admission and proportion of infants small for gestational age between two groups (P>0.05). There was no significant difference in the healthy status and other perinatal parameters between late preterm infants group and full-term infants group (P>0.05). Apnea was only found in late preterm infants group, and NO inhalation treatment and high frequency ventilation were only adopted in full-term infants group, while there was no significant difference in the main disease diagnosis, respiratory treatment modality and prognosis between two groups (P>0.05). The proportion of infants small for gestational age in favorable prognosis group was significantly lower than that in unfavorable prognosis group (P<0.05), while the Caesarean section rate in favorable prognosis group was significantly higher than that in unfavorable prognosis group (P<0.05). Conclusion Relationship between gestational age and body weight of neonates with respiratory failure and way of delivery are influencing factors of prognosis.

Key words: late preterm infant, full-term infant, neonatal respiratory failure, incidence, prognosis, risk factor