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Association analysis of social and psychological factors and 5-hydroxytryptamine transporter gene to asthma susceptibility

XU Jian-guo1, LIN Jian-yan2, MA Ying-jiao3, LIAO Jian-ying3, LIANG Jian-cheng3   

  1. 1.Department of Respiratory Disease, the Affiliated Hospital of Youjiang Medical College for Nationalities, Baise 533000, China； 2.Nanning Municipal Center for Disease Control and Prevention， Nanning 530011， China； 3.School of Public Health and Management, Youjiang Medical College for Nationalities, Baise 533000， China
  • Online:2014-01-28 Published:2014-01-29
  • Supported by:

    National Natural Science Foundation of China，81060004； Scientific Research Project of Education Department of Guangxi Zhuang Autonomous Region，201106LX456； Scientific Research Project of Health Bureau of Guangxi Zhuang Autonomous Region， Z2011144

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Abstract:

Objective To investigate effects of the social and psychological factors and 5-hydroxytryptamine transporter (5-HTT) gene to asthma susceptibility in Han nationality in Guangxi Zhuang Autonomous Region. Methods IDA (irritability, depression, and anxiety scale), TCSQ (trait coping style questionnaire), SSRS (social support rating scale), and general situation investigation list were used to evaluate the social and psychological factors on 175 asthma patients and 180 healthy people as control group. Genotypes and alleles of Stin2 and 5-HTTLPR/rs25331 polymorphism were examined with polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique. Results Logistic regression analysis showed that high level of education and subjective support were protective factors for asthma (OR=0.288, P=0.000; OR=0.898, P=0.000), while inward irritability was a risk factor (OR=1.205, P=0.011). There was no significant difference between asthma and control group with the Stin2, 5-HTTLPR/rs25331 genotype, and allele frequencies (P>0.05). Conclusion Some of the social and psychological factors play important roles in the pathogenesis of asthma, but it is still uncertain if 5-HTT gene polymorphism is relevant to the pathogenesis of asthma.

Key words: 5-hydroxytryptamine transporter gene, social and psychological factors, asthma