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Advances in application of induced pluripotent stem cells in neurological diseases

MA Chen-kai, MA Jie   

  1. Department of Paediatric Neurosurgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    National Major Science Research Project,2010CB945203;  National Natural Science Foundation of China, 81271382


Induced pluripotent stem cells (iPSCs) technology reprograms differentiated somatic cells and induces them to pluripotent stem cells. At present many novel technologies have improved the transfection efficiency and clinical safety of iPSCs. Neural precursor cells, glial cells, and neuron-like cells derived from iPSCs can be transplanted to treat neurological diseases and the results show good prospects. The iPSCs technology can also be used to establish models of relevant diseases in vitro and screen drugs. This paper reviews the applications of iPSCs in neurological diseases.

Key words: induced pluripotent stem cells, neurological diseases, drugs profiling