›› 2012, Vol. 32 ›› Issue (5): 667-.doi: 10.3969/j.issn.1674-8115.2012.05.030

• Review • Previous Articles     Next Articles

Research progress of induced pluripotent stem cells in liver diseases

SUN Chao, FAN Jian-gao   

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2012-05-28 Published:2012-06-01
  • Supported by:

    National Natural Science Foundation of China, 81000173


Stem cells, especially induced pluripotent stem cells (iPS cells), could differentiate into functional hepatocytes and avoid the ethical issues in the application of embryonic stem cells. Therefore, stem cells may serve as new seed cells for the replacement therapy for end-stage hepatic diseases. The experimental methods, research findings and clinical prospects of iPS cells in liver diseases are introduced in this paper, in hopes of providing references for the basic research and clinical practice of treatment of liver diseases.

Key words: induced pluripotent stem cells, liver diseases, hepatic lineage, cell transplantation