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Correlation between HIF-1α and MMPs in synovial tissues of patients with rheumatoid arthritis

ZHAI Tian-hang , ZHANG Jie, LI Hui-dan, HUO Rong-fen, SHEN Bai-hua, LI Ning-li   

  1. Shanghai Institute of Immunology, Shanghai 200025, China
  • Online:2015-09-28 Published:2015-09-30
  • Supported by:

    National Natural Science Foundation of China，81172856; Foundation of Science and Technology Commission of Shanghai Municipality， 12JC1407700，12401903702

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Abstract:

Objective  To investigate the correlation between the expression of hypoxia-inducible factor-1α (HIF-1α) and the expression of matrix metalloproteinases (MMPs) in synovial tissues of patients with rheumatoid arthritis (RA). Methods  The  expressions of HIF-1α and MMPs in synovial tissues of patients with RA and osteoarthritis (OA) were detected by real-time PCR and the correlation analysis was conducted. Results  The mRNA expressions of HIF-1α, MMP-1, MMP-3, MMP-9, and MMP-13 in synovial tissues of patients with RA were significantly higher than those of patients with OA. Highly expressed HIF-1α in synovial tissues of patients with RA significantly and positively correlated with MMP-9. Conclusion  Highly expressed HIF-1α in synovial tissues of patients with RA may involve in the regulation of the expression of MMP-9 and the process of pathological change of RA.

Key words: rheumatoid arthritis, hypoxia-inducible factor-1α, matrix metalloproteinase