• Original article (Clinical research) • Previous Articles     Next Articles

Metabolism-related high risk factors for obstructive sleep apnea hypopnea syndrome in adolescent obese patients

ZHANG Yu-wen, SHI Juan, ZHANG Yi-fei, GU Wei-qiong, WANG Wei-qing, HONG Jie   

  1. Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    National Natural Science Foundation of China, 81270931


Objective · To explore the high risk factors for obstructive sleep apnea hypopnea syndrome (OSAHS) in adolescent obese patients. Methods · A total of 199 adolescent obese patients were enrolled. All patients underwent polysomnography (PSG). The severity of OSAHS was assessed with apnea hypopnea index (AHI). The homeostasis model assessment-insulin resistance index (HOMA-IR) was calculated using steady-state model. Bergman mini-model technology and frequently sampled intravenous glucose tolerance test were used to calculate the insulin sensitivity index (SI). The abdominal fat distribution and content were measured with CT and specific software. Patients were stratified and compared by OSAHS and severity and regression analysis was used to predict the high risk factors for OSAHS in this population. Results · The OSAHS group had significantly larger neck circumference (NC) and higher visceral fat area (VAT), blood pressure, blood glucose, liver enzyme, and blood lipid than the non-OSAHS group (P<0.05). Among above factors, NC, VAT, and diastolic blood pressure (DBP) are independent risk factors for OSAHS. Conclusion · Larger NC and higher VAT and DBP are high risk factors for OSAHS in adolescent obese patients.

Key words: obesity, obstructive sleep apnea hypopnea syndrome, neck circumference, visceral adipose tissue, blood pressure