Abstract: Objective · To explore the correlation between serum uric acid level and subclinical target organ damage. Methods · A cohort of 333 patients were recruited at the Department of Examination Center of Ruijin Hospital North in July 2017, who were divided into two groups, normal (n248) and high levels (n85, males >420 μmol/L, females >360 μmol/L) of serum uric acid. Subclinical target organ damage indexes included glomerular filtration rate (eGFR), left ventricular mass index (LVMI) and other indicators. Results · Systolic pressure (P0.006), diastolic pressure (P0.000), serum creatinine (P0.000) and LVMI (P0.028) in the high uric acid group were significantly higher than those in the normal uric acid group, and eGFR was significantly lower than that of the control group (P0.000). Pearson correlation analysis showed that the serum uric acid level was significantly correlated with systolic pressure (r0.149, P0.007), diastolic pressure (r0.269, P0.000), LVMI (r0.172, P0.002) and serum creatinine (r0.569, P0.000), and negatively correlated with glomerular filtration rate (r-0.383, P0.000). After adjusting to sex, age, and BMI, there was a significant positive correlation with diastolic pressure (r0.170, P0.013), and a significant negative correlation with glomerular filtration rate (r-0.332, P0.000). After further adjusting to blood pressure, there was a significant negative correlation with glomerular filtration rate (r-0.291, P0.000). Multivariate linear regression analysis showed that serum uric acid was independent of diastolic pressure and glomerular filtration rate (β0.162, P0.000; β-0.058, P0.004). Conclusion · Serum uric acid is positively correlated with diastolic blood pressure, and is negatively correlated with glomerular filtration rate.

Key words: serum uric acid, systolic blood pressure, diastolic blood pressure, glomerular filtration rate, left ventricular mass index