Abstract:

Objective To analyse the relationship between estimated glomerular filtration rate (eGFR) and ^99mTc-glomerular filtration rate (^99mTc-GFR), and explore the suitable methods for eGFR of Chinese inpatients with chronic kidney disease (CKD). Methods One thousand and thirty-three inpatients with CKD were selected, ^99mTc-GFR was measured by ^99mTc-diethylenetriaminepentaacetic acid (^99mTc-DTPA) dynamic renal imaging, and serum creatinine (SCr) was determined by enzymatic method. Cockcroft-Gault formula, modification of diet in renal disease (MDRD) equation, abbreviated MDRD equation, MDRD equation for Chinese, abbreviated MDRD equation for Chinese and CKD-EPI equation were employed for calculation and body surface area (BSA) was used for correction of eGFR (C-G GFR, 7GFR, aGFR, c-7GFR4, c-aGFR4 and CKD-EPI-GFR, respectively). The relationship between ^99mTc-GFR and eGFR was analysed. Results Correlation regression analysis revealed that the correlation coefficients between C-G GFR, 7GFR, aGFR, c-7GFR4, c-aGFR4, CKD-EPI-GFR and ^99mTc-GFR were 0.805, 0.797, 0.783, 0.791, 0.777 and 0.800, respectively, and the differences were -2.46, -14.24, -16.53, -20.92, -22.92 and -13.56, respectively. There was approximate hyperbolic relation between ^99mTc-GFR and SCr. Conclusion C-G GFR is most closely related to ^99mTc-GFR among eGFR from SCr, C-G formula may be a suitable method for eGFR of Chinese inpatients with CKD when SCr is measured by enzymatic method.

Key words: glomerular filtration rate, estimated glomerular filtration rate, serum creatinine, Cockcroft-Gault formula, MDRD equation, CKD-EPI equation, relationship