›› 2010, Vol. 30 ›› Issue (11): 1376-.doi: 10.3969/j.issn.1674-8115.2010.11.014

• Original article (Clinical research) • Previous Articles     Next Articles

Relationship between estimated glomerular filtration rate from serum creatinine and 99mTc-glomerular filtration rate

GU Hong-xia1,2, Qin Li2, FU Hong-liang3, WANG Hui3, SU Qing2   

  1. 1.Department of Endocrinology &|Metabolism, Xinhua Hospital Chongming Branch, Shanghai Jiaotong University School of Medicine, Shanghai 202150, China; 2.Department of Endocrinology &|Metabolism, 3.Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2010-11-25 Published:2010-11-29


Objective To analyse the relationship between estimated glomerular filtration rate (eGFR) and 99mTc-glomerular filtration rate (99mTc-GFR), and explore the suitable methods for eGFR of Chinese inpatients with chronic kidney disease (CKD). Methods One thousand and thirty-three inpatients with CKD were selected, 99mTc-GFR was measured by 99mTc-diethylenetriaminepentaacetic acid (99mTc-DTPA) dynamic renal imaging, and serum creatinine (SCr) was determined by enzymatic method. Cockcroft-Gault formula, modification of diet in renal disease (MDRD) equation, abbreviated MDRD equation, MDRD equation for Chinese, abbreviated MDRD equation for Chinese and CKD-EPI equation were employed for calculation and body surface area (BSA) was used for correction of eGFR (C-G GFR, 7GFR, aGFR, c-7GFR4, c-aGFR4 and CKD-EPI-GFR, respectively). The relationship between 99mTc-GFR and eGFR was analysed. Results Correlation regression analysis revealed that the correlation coefficients between C-G GFR, 7GFR, aGFR, c-7GFR4, c-aGFR4, CKD-EPI-GFR and 99mTc-GFR were 0.805, 0.797, 0.783, 0.791, 0.777 and 0.800, respectively, and the differences were -2.46, -14.24, -16.53, -20.92, -22.92 and -13.56, respectively. There was approximate hyperbolic relation between 99mTc-GFR and SCr. Conclusion C-G GFR is most closely related to 99mTc-GFR among eGFR from SCr, C-G formula may be a suitable method for eGFR of Chinese inpatients with CKD when SCr is measured by enzymatic method.

Key words: glomerular filtration rate, estimated glomerular filtration rate, serum creatinine, Cockcroft-Gault formula, MDRD equation, CKD-EPI equation, relationship