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Study on the effects of drug treatment on the behavioral inhibition/activation systems in patients with obsessive-compulsive disorder

GAO Rui, FAN Qing, ZHANG Zong-feng, CAO Xuan, CHEN Yong-jun, BAI Yan-le, ZHANG Hai-yin   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH 2011-873；Shanghai Science and Technology Commission “Science and Technology Innovation Action Plan”Supporting Project Sub Topics in the Field of Medicine and Agriculture, 15411950203；The Key Characteristic Specialist Department of Shanghai Mental Health Center, 2013-YJTSZK-02；The Research Fund of Shanghai Mental Health Center, 2013-YJ-01

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Abstract:

Objective · To investigate the effects of drug treatment on the behavioral inhibition system (BIS) and behavioral activation system (BAS) in patients with obsessive-compulsive disorder (OCD). Methods · A total of 35 patients with OCD and 35 healthy controls were enrolled. The Yale-Browan obsessive compulsive scale (YBOCS) and behavioral inhibition system and behavioral activation system scale (BIS/BAS) were used for baseline assessment. OCD patients received drug treatment for three months. Then YBOCS and BIS/BAS were used again for follow-up assessment. The differences in BIS and BAS between the OCD and control groups, before and after drug treatment, and different efficacy groups were compared. Results · The BIS in the OCD group was significantly different from that in the control group (F=34.255, P=0.000). There was a significant difference in BIS before and after drug treatment (t=-2.302, P=0.028). Also there was a significant difference in the main effect of behavioral activation system scale-fun seeking (BASF) between different efficacy groups when controlling the basic YBOCS score before and after drug treatment (F=4.868, P=0.035). The main effect of efficacy on the BIS was significant (F=4.500, P=0.019). Conclusion · The activity of BIS in OCD patients was poorer than that of healthy controls. With the change of severity of OCD symptoms, the inhibition function of OCD changed as well. There was a significant difference in the BASF in different efficacy groups before and after drug treatment.

Key words: obsessive-compulsive disorder, drug therapy, behavioral activation system, behavioral inhibition system