Objective · To evaluate the efficacy of group cognitive-behavior therapy to late-life depression (LLD) and investigate the feature of LLD patients who adapt GCBT. Methods · 37 LLD patients were enrolled. The duration of GCBT was 12 weeks. The efficacy of GCBT was evaluated by Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA) and Geriatric Depression Scale (GDS) before and after treatment. Demographic and clinical characteristics of completed group and dropped out group were compared. Results · 20 patients were accomplished the GCBT in 12 weeks. The score of HAMD, HAMA and GDS were significant declined compared to the baseline. Completed group and dropped out group hadn’t any difference in the age, sex, work type and severity of disease. The education level of LLD patients in different groups was significantly different. Conclusion · GCBT can improve the depression and anxiety symptoms of LLD patient. Patients with higher education level are appropriate candidates for GCBT.