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Research advances in the mechanism of osteoarthritis caused by the mechanical instability

JI An-qi, DENG Guo-ying, WANG Qiu-gen, WANG Qian   

  1. Department of Orthopedics, Trauma Center, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai 201600, China
  • Online:2017-04-28 Published:2017-05-04
  • Supported by:

    Shanghai Municipal Science and Technology Commission Guidance Project, 15411968800; Shanghai Natural Science Foundation, 13ZR1433300; The Preliminary Plan of Excellent Medical Young Talents Training in Shanghai General Hospital, 061417; Discipline Construction Funds of Trauma Emergency Center of Shanghai General Hospital, 1304


Osteoarthritis is a common articular cartilage degenerative disease and the main cause is mechanical instability. The mechanical instability can reduce the number of chondrocytes and destroy extracellular matrix through direct injury, inducing cell apoptosis, and stimulating the production of inflammatory factors, leading to decrease of matrix type II collagen and proteoglycan and degeneration of cartilage. Long-term cartilage degeneration can result in osteoarthritis. Therefore, understanding how mechanical instability leads to the incidence of osteoarthritis can better improve the course of osteoarthritis from the perspective of mechanics.

Key words: osteoarthritis, mechanical instability, extracellular matrix