JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 617-621.doi: 10.3969/j.issn.1674-8115.2021.05.009

• Clinical research • Previous Articles     Next Articles

Diagnostic value of preablative stimulated thyroglobulin for recurrence or metastases of differentiated thyroid carcinoma complicated with nodular goitre

Hong CHAI(), Qin HUANG, Ze-quan CHEN, Jia-huan YANG, Yong-li YU()   

  1. Department of Nuclear Medicine, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 201306, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Yong-li YU E-mail:chaihongggg@126.com;yuyongli000@126.com
  • Supported by:
    Shanghai Municipal Commission of Health and Family Planning(20164Y0202)

Abstract: Objective

·To evaluate the role of preablative stimulated thyroglobulin (ps-Tg) as an early prognostic marker for patients with differentiated thyroid carcinoma (DTC) complicated with nodular goitre (NG) after operation and determine the corresponding cut-off value.

Methods

·A total of 268 patients with DTC complicated with NG who underwent the 131I treatment and thyroidectomy were analyzed. Logistic regression analysis were performed to evaluate baseline ps-Tg and other clinicopathologic characteristics in the prediction of distant metastasis. The receiver operating characteristic (ROC) curve analysis was conducted to analyze optimal cut-off point of ps-Tg for predicting the recurrence or metastasis for patients with DTC complicated with NG.

Results

·In the Logistic analysis, ps-Tg (OR=1.002, P=0.005), N1b (OR=0.235, P=0.001) and the histological-pathological types (OR=0.263, P=0.012) were predictors of distant metastasis. The cut-off value of ps-Tg for predicting the recurrence or metastasis was 26.97 ng/mL, with sensitivity of 66.7% and specificity of 83.3%. Area under the ROC curve was 0.795.

Conclusion

·For patients with DTC complicated with NG, ps-Tg, N1b and the histological- pathological types have a significant prognostic implication in early postoperative metastasis or recurrence. The cut off value of ps-Tg could be more useful for the prediction of metastasis or recurrence.

Key words: differentiated thyroid carcinoma (DTC), nodular goitre (NG), preablative stimulated thyroglobulin (ps-Tg)

CLC Number: