JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 653-658.doi: 10.3969/j.issn.1674-8115.2021.05.016

• Review • Previous Articles     Next Articles

Short- and long-term effects of frozen-thawed embryo transfer on offspring

Ning-xin QIN1,2(), Wen-long ZHAO1,2, Zhi-yang ZHOU1,2, Wei-hui SHI1,2, Yan-ting WU1,2,3, He-feng HUANG1,2,3()   

  1. 1.Institute of Embryo Original Diseases, the International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
    2.Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China
    3.Institute of Reproductive and Developmental Research, Fudan University, Shanghai 200032, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: He-feng HUANG;
  • Supported by:
    National Key R&D Program of China(2017YFC1001300);National Natural Science Foundation of China(81661128010)


Frozen-thawed embryo transfer (FET) is one of the commonly used assisted reproductive technology. Because FET has the advantages of high cumulative pregnancy rate and low incidence of ovarian hyperstimulation syndrome, the number of offspring born through this technology is increasing year by year. Many studies have shown that the risks of preterm delivery, low birth weight and small for gestation age of FET offspring are lower than those of the offspring born in the fresh embryo transfer cycle. There is also evidence that the risks of macrosomia and large for gestational age of FET offspring are higher. At the same time, there are also reports on the long-term health status of FET offspring in childhood and adulthood. This paper reviews the short-term and long-term effects of FET on offspring and the causes.

Key words: assisted reproductive technology (ART), frozen-thawed embryo transfer (FET), offspring, short-term effect, long-term effect

CLC Number: