JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (7): 967-971.doi: 10.3969/j.issn.1674-8115.2021.07.020

• Review • Previous Articles    

Research progress of the role of gut microbiota in the pathogenesis and treatment of obsessive-compulsive disorder

Ying-dan ZHANG(), Zhen WANG()   

  1. Department of Clinical Psychology, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Zhen WANG;
  • Supported by:
    Program of Shanghai Academic Research Leader(20XD1423100);Grants from Shanghai Municipal Health Commission for Key Developing Disciplines-Psychosomatic Medicine Program(2019ZB0201)


Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder characterized by recurrent intrusive thoughts or repetitive behaviors. However, the etiology is complex and the underlying pathophysiology remains unclear. In recent years, microbiota-gut-brain (MGB) axis has become a research hotspot in the field of psychiatry. Gut microbiota, as a key medium of the bilateral connection between brain and intestine, plays an important role in immune inflammation, neuroendocrine and brain development. This review illustrates possible link between OCD and MGB axis and the underlying etiological pathway. And treatment options targeting the gut microbiome is also further discussed.

Key words: obsessive-compulsive disorder (OCD), microbiota-gut-brain axis, gut microbiota

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