Research progress of the role of gut microbiota in the pathogenesis and treatment of obsessive-compulsive disorder

doi:10.3969/j.issn.1674-8115.2021.07.020

Abstract

Abstract:

Obsessive-compulsive disorder (OCD) is a chronic and disabling psychiatric disorder characterized by recurrent intrusive thoughts or repetitive behaviors. However, the etiology is complex and the underlying pathophysiology remains unclear. In recent years, microbiota-gut-brain (MGB) axis has become a research hotspot in the field of psychiatry. Gut microbiota, as a key medium of the bilateral connection between brain and intestine, plays an important role in immune inflammation, neuroendocrine and brain development. This review illustrates possible link between OCD and MGB axis and the underlying etiological pathway. And treatment options targeting the gut microbiome is also further discussed.

Key words: obsessive-compulsive disorder (OCD), microbiota-gut-brain axis, gut microbiota

CLC Number:

R749.99

Ying-dan ZHANG, Zhen WANG. Research progress of the role of gut microbiota in the pathogenesis and treatment of obsessive-compulsive disorder[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(7): 967-971.

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