Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (10): 1490-1497.doi: 10.3969/j.issn.1674-8115.2022.10.016

• Review • Previous Articles    

Research progress in the role of Akkermansia muciniphila in gut-related diseases

JIANG Yi1(), JIANG Ping2, ZHANG Mingming1, FANG Jingyuan1()   

  1. 1.Shanghai Institute of Digestive Disease, Department of Gastroenterology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China
    2.Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210093, China
  • Received:2022-05-07 Accepted:2022-08-28 Online:2022-10-17 Published:2022-10-17
  • Contact: FANG Jingyuan;
  • Supported by:
    National Natural Science Foundation of China(81970487)


Akkermansia muciniphila (A. muciniphila) is one of the normal gut symbionts using mucin as the sole source of carbon and nitrogen elements to maintain colonization and growth. Intestinal homeostasis is crucial for maintaining physiological functions. Intestinal dysfunction is closely related to the occurrence and development of metabolic diseases, immune diseases, infectious diseases and tumors. Gut microbiota is a key factor that influences the intestinal health. As a member of the gut microbes, A. muciniphila plays a convincing role in intestinal inflammation, intestinal tumor and other intestinal disorders involving diseases such as liver diseases and metabolic diseases. The mechanism is under exploration and revealed gradually. Hence, A. muciniphila is considered to be a promising candidate of probiotics. The characteristics of A. muciniphila, its distribution in the gut, its relationship with gut-related diseases and the mechanism are reviewed.

Key words: Akkermansia muciniphila (A. muciniphila), inflammation, tumor, probiotics, gut microbiota

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