Abstract:

Rheumatoid arthritis (RA) is a chronic symmetrical disease with synovial inflammation, bone destruction and pannus formation. Inflammatory mediators are closely related to the pathogenesis of RA, and the severity of RA is significantly affected by the promotion and demotion of inflammatory mediator levels. In this review, we have reviewed the studies about the correlation between cytokine signaling inhibitory factors and RA in recent years. We have found that cytokine signaling inhibitory factors, as endogenous negative regulators, are involved in intra- and extra-cellular signal transduction, mediating T cell survival and differentiation, inducing transcription and activation of inflammatory factors, and playing a regulatory role in the activation of various immune responses invivovia blocking the phosphorylation of signal transducer and activator of transcription (STAT) and inhibiting the activity of Janus kinase (JAK). Therefore, as an anti-inflammatory mediator protein, cytokine signaling inhibitory factors are involved in inflammatory responses via various pathways, closely related to the occurrence and development of RA, and are expected to be a biomarker for the diagnosis and prognosis for RA. Meanwhile, we predict that the study of apoptosis, immune regulation, cartilage metabolism and autophagy related to cytokine signaling inhibitors may become a research hotspot for RA in the future. Further in-depth research on the correlation and mechanism of cytokine signaling inhibitory factors and RA may widen our vision for the treatment of RA.

Key words: rheumatoid arthritis (RA), suppressor of cytokine signaling (SOCS), inflammation, JAK/STAT signaling pathway, NF-κB signaling pathway, MAPK signaling pathway