Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (6): 786-791.doi: 10.3969/j.issn.1674-8115.2022.06.013

• Clinical research • Previous Articles    

Study on the interaction between body weight and C1q tumour necrosis factor-related protein 1 in patients with myocardial infarction

HU Xiao(), ZHANG Xin, GU Yang()   

  1. Department of Cardiology, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huai'an 223300, China
  • Received:2022-01-20 Accepted:2022-06-01 Online:2022-06-28 Published:2022-08-19
  • Contact: GU Yang;
  • Supported by:
    Cardiovascular Multidisciplinary Thinking Research Fund of China International Medical Foundation(Z-2016-23-2101-46);Natural Science Research Program of Huai'an(HAB202025)

Abstract: Objective

·To investigate relationship between body weight and serum level of C1q tumor necrosis factor-related protein 1 (CTRP1), and its effect on the prognosis of patients with ST-segment elevation myocardial infarction (STEMI).


·A total of 200 patients diagnosed as STEMI in the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University from January 2018 to January 2020 were selected. Their basic data, laboratory indexes and cardiac function indexes were collected and analyzed. After discharge, patients should continue to take oral drugs and have regular outpatient or telephone follow-up. According to whether serious adverse event (SAE) occurred or not within 1 year after discharge, patients were divided into SAE group and non-SAE group. Multivariate Logistic regression model was used to analyze the influencing factors of SAE in STEMI patients. The interaction between gender, age and body weight of patients and the serum level of CTRP1 was analyzed by forest plot.


·A total of 192 patients were followed up. Among them, 24 patients (12.5%) developed SAE. Compared with the non-SAE group, patients in the SAE group were older [(67.08±10.30) years vs (62.99±9.04) years, P=0.043], had lower body weight [(65.41±9.45) kg vs (70.49±10.23) kg, P=0.023)], and had higher CTRP1 levels [(21.59±4.48) ng/mL vs (17.67±5.87) ng/mL, P=0.002)]. After adjusting for gender and age, multivariate Logistic regression analysis showed that high CTRP1 level was a risk factor for the incidence of SAE in STEMI patients (P=0.003), while body weight had no effect on the incidence of SAE (P>0.05). The results of subgroup analysis showed that there was an interaction between body weight and CTRP1 (P=0.011), and CTRP1 level was a risk factor for SAE occurring in patients with lower body weight (HR=22.303, P=0.003).


·There is an interaction between body weight and serum CTRP1 level in STEMI patients. The higher the level of serum CTRP1 in STEMI patients with lower body weight, the worse the prognosis they have.

Key words: C1q tumor necrosis factor-related protein 1 (CTRP1), ST-segment elevation myocardial infarction (STEMI), interaction, serious adverse event (SAE)

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