Journal of Shanghai Jiao Tong University (Medical Science) ›› 2024, Vol. 44 ›› Issue (1): 50-63.doi: 10.3969/j.issn.1674-8115.2024.01.006
• Clinical research • Previous Articles Next Articles
MA Jinqian1,2(), FAN Pianpian1(), ZHENG Tao1,3, ZHANG Lin3,4, CHEN Yuanzhi1, SHEN Jian5, OUYANG Fengxiu1,2()
Received:
2023-06-09
Accepted:
2023-12-05
Online:
2024-01-28
Published:
2024-02-28
Contact:
OUYANG Fengxiu
E-mail:mjq18335988098@126.com;447259743@qq.com;ouyangfengxiu@xinhuamed.com.cn
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CLC Number:
MA Jinqian, FAN Pianpian, ZHENG Tao, ZHANG Lin, CHEN Yuanzhi, SHEN Jian, OUYANG Fengxiu. Relationship among maternal gut, vaginal microbiota and microbiota in meconium and vernix caseosa in newborns[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2024, 44(1): 50-63.
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URL: https://xuebao.shsmu.edu.cn/EN/10.3969/j.issn.1674-8115.2024.01.006
Characteristic | Value | Characteristic | Value |
---|---|---|---|
Maternal characteristic (n=11) | Weight gain in mid to late pregnancy/kg | 12.69±4.50 | |
Age/year | 29.00±4.03 | Gestational diabetes mellitus/n(%) | 1(9.1) |
Education level/n(%) | GBS positive/n(%) | 0(0) | |
High school or below | 3(27.3) | Puerperal fever/n(%) | 0(0) |
College or above | 8(72.7) | Infant characteristic (n=11) | |
Parity/n(%) | Infant gender/n(%) | ||
0 | 8(72.7) | Girl | 4(36.4) |
≥1 | 3(27.3) | Boy | 7(63.6) |
Antibiotics use during child delivery/n(%) | Weight for gestational age/n(%) | ||
No | 8(72.7) | SGA | 2(18.2) |
Yes | 3(27.3) | AGA | 8(72.7) |
Early pregnancy BMI/n(%) | LGA | 1(9.1) | |
<18.5 kg·m-2 | 0(0) | Entering NICU after birth/n(%) | |
18.5‒23.9 kg·m-2 | 8(72.7) | Yes | 1 (9.1) |
24.0‒27.9 kg·m-2 | 1(9.1) | No | 10(90.9) |
≥28 kg·m-2 | 2(18.2) | Gestational age at birth/week | 40.18±0.75 |
Pre-delivery BMI/n(%) | Length/cm | 50.27±1.62 | |
<18.5 kg·m-2 | 0(0) | Birth weight/g | 3 536.36±423.66 |
18.5‒23.9 kg·m-2 | 0(0) | Head circumference/cm | 34.55±1.21 |
24.0‒27.9 kg·m-2 | 6(54.5) | Birth BMI/(kg·m-2) | 13.96±1.15 |
≥28 kg·m-2 | 5(45.5) | Neonatal antibiotics use/n(%) | 0(0) |
Tab 1 Clinical characteristics of 11 pairs of mothers and newborns
Characteristic | Value | Characteristic | Value |
---|---|---|---|
Maternal characteristic (n=11) | Weight gain in mid to late pregnancy/kg | 12.69±4.50 | |
Age/year | 29.00±4.03 | Gestational diabetes mellitus/n(%) | 1(9.1) |
Education level/n(%) | GBS positive/n(%) | 0(0) | |
High school or below | 3(27.3) | Puerperal fever/n(%) | 0(0) |
College or above | 8(72.7) | Infant characteristic (n=11) | |
Parity/n(%) | Infant gender/n(%) | ||
0 | 8(72.7) | Girl | 4(36.4) |
≥1 | 3(27.3) | Boy | 7(63.6) |
Antibiotics use during child delivery/n(%) | Weight for gestational age/n(%) | ||
No | 8(72.7) | SGA | 2(18.2) |
Yes | 3(27.3) | AGA | 8(72.7) |
Early pregnancy BMI/n(%) | LGA | 1(9.1) | |
<18.5 kg·m-2 | 0(0) | Entering NICU after birth/n(%) | |
18.5‒23.9 kg·m-2 | 8(72.7) | Yes | 1 (9.1) |
24.0‒27.9 kg·m-2 | 1(9.1) | No | 10(90.9) |
≥28 kg·m-2 | 2(18.2) | Gestational age at birth/week | 40.18±0.75 |
Pre-delivery BMI/n(%) | Length/cm | 50.27±1.62 | |
<18.5 kg·m-2 | 0(0) | Birth weight/g | 3 536.36±423.66 |
18.5‒23.9 kg·m-2 | 0(0) | Head circumference/cm | 34.55±1.21 |
24.0‒27.9 kg·m-2 | 6(54.5) | Birth BMI/(kg·m-2) | 13.96±1.15 |
≥28 kg·m-2 | 5(45.5) | Neonatal antibiotics use/n(%) | 0(0) |
Characteristic | Value | Characteristic | Value |
---|---|---|---|
Maternal characteristic (n=14) | Weight gain in mid to late pregnancy/kg | 11.09±9.63 | |
Age/year | 30.43±2.90 | Gestational diabetes mellitus/n(%) | 1(7.1) |
Education level/n(%) | GBS positive/n(%) | 0(0) | |
High school or below | 3(21.4) | Puerperal fever/n(%) | 0(0) |
College or above | 11(78.6) | Infant characteristic (n=14) | |
Parity/n(%) | Infant gender/n(%) | ||
0 | 10(71.4) | Girl | 7(50.0) |
≥1 | 4(28.6) | Boy | 7(50.0) |
Antibiotics use during child delivery/n(%) | Weight for gestational age/n(%) | ||
No | 11(78.57) | SGA | 0(0) |
Yes | 3(21.43) | AGA | 10(71.4) |
Early pregnancy BMI/n(%) | LGA | 4(28.6) | |
<18.5 kg·m-2 | 0(0) | Entering NICU after birth/n(%) | |
18.5‒23.9 kg·m-2 | 11(78.6) | Yes | 2(14.3) |
24.0‒27.9 kg·m-2 | 2(14.3) | No | 12(85.7) |
≥28 kg·m-2 | 1(7.1) | Gestational age at birth/week | 39.14±0.95 |
Pre-delivery BMI/n(%) | Length/cm | 50.00±0.88 | |
<18.5 kg·m-2 | 0(0) | Birth weight/g | 3 418.93±371.51 |
18.5‒23.9 kg·m-2 | 2(14.3) | Birth BMI/(kg·m-2) | 13.66±1.26 |
24.0‒27.9 kg·m-2 | 8(57.1) | Neonatal antibiotics use/n(%) | 0(0) |
≥28 kg·m-2 | 4(28.6) | - | - |
Tab 2 Clinical characteristics of 14 newborns and their mothers
Characteristic | Value | Characteristic | Value |
---|---|---|---|
Maternal characteristic (n=14) | Weight gain in mid to late pregnancy/kg | 11.09±9.63 | |
Age/year | 30.43±2.90 | Gestational diabetes mellitus/n(%) | 1(7.1) |
Education level/n(%) | GBS positive/n(%) | 0(0) | |
High school or below | 3(21.4) | Puerperal fever/n(%) | 0(0) |
College or above | 11(78.6) | Infant characteristic (n=14) | |
Parity/n(%) | Infant gender/n(%) | ||
0 | 10(71.4) | Girl | 7(50.0) |
≥1 | 4(28.6) | Boy | 7(50.0) |
Antibiotics use during child delivery/n(%) | Weight for gestational age/n(%) | ||
No | 11(78.57) | SGA | 0(0) |
Yes | 3(21.43) | AGA | 10(71.4) |
Early pregnancy BMI/n(%) | LGA | 4(28.6) | |
<18.5 kg·m-2 | 0(0) | Entering NICU after birth/n(%) | |
18.5‒23.9 kg·m-2 | 11(78.6) | Yes | 2(14.3) |
24.0‒27.9 kg·m-2 | 2(14.3) | No | 12(85.7) |
≥28 kg·m-2 | 1(7.1) | Gestational age at birth/week | 39.14±0.95 |
Pre-delivery BMI/n(%) | Length/cm | 50.00±0.88 | |
<18.5 kg·m-2 | 0(0) | Birth weight/g | 3 418.93±371.51 |
18.5‒23.9 kg·m-2 | 2(14.3) | Birth BMI/(kg·m-2) | 13.66±1.26 |
24.0‒27.9 kg·m-2 | 8(57.1) | Neonatal antibiotics use/n(%) | 0(0) |
≥28 kg·m-2 | 4(28.6) | - | - |
Fig 2 Box plots of Ace (A), Chao1 (B), Shannon (C), and Simpson (D) indices of maternal gut microbiota and vaginal microbiota in late-pregnancy and neonatal meconium microbiota
Fig 6 Species composition heatmaps at the level of phylum (A) and genus (B) in the maternal gut microbiota and maternal vaginal microbiota in late-pregnancy and neonatal meconium microbiota
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